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As part of the definition of CSC, these cells not only had to have theability to self-renew (repeated passage in xenogenic host while retaining genetic identifiers),but also in this setting, had to give rise to non-stem cell tumor populations that were a mirrorimage of the original patient tumor populations (Reya 2001).
However, it is important to understand this lymphocyteLAG/MHC-class II interaction because it causes a lot of problems when DCs are used duringanti-cancer immunotherapeutic treatments, which will be discussed at length in the future.Once DCs mature there is an increase of certain cell surface proteins that enable the DC tocommunicate with T cells in a positive manner. (2010) Cognition, reserve, andamyloid deposition in normal aging.
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